Our studies focus entirely on human diseases and on the contributions of genetics to disease susceptibility. We are particularly interested in disorders in which genetic factors interact with environmental factors to increase the risk of disease. Our studies range from relatively rare disorders arising from mutations in single genes to complex disorders that involve the actions, and possible interactions, of multiple unidentified genes and environmental exposures.
Genetics of Malnutrition We are exploring the hypothesis that genetic factors may contribute to a child’s risk of stunting in an environmental context of poor sanitation and endemic disease. To address this hypothesis, we are carrying out a genome-wide association study (GWAS) in a well characterized cohort of children recruited in Dhaka, Bangladesh. more . .
Radiation Sensitivity For more than 20 years, we have studied the genetics of radiosensitivity in humans, focusing on known recessive genetic disorders that result in the most extreme ionizing radiation hypersensitivity phenotypes. more . .
Contralateral Breast Cancer The increasing incidence of breast cancer, coupled with improved survival after cancer diagnosis, places an increasing number of women at risk for developing a second primary breast cancer, yet the genetic epidemiology of second primary breast cancer is complex and poorly understood. more . . .
Type 1 Diabetes Genetics Our studies of T1D have focused on defining the genetic risk factors that contribute to susceptibility to this disorder with the goals of better understanding the underlying pathology, and facilitating preventive approaches through early diagnosis and novel therapies. more . . .