Farber lab study reveals novel regulatory mechanisms governing bone formation

A research team, led by the Farber lab in the Center for Public Health Genomics and collaborators at UCLA and the University of Namur in Belgium, has used a systems-based approach to identify gene networks that govern the activity of bone cells.  The group used genome-wide gene expression data across a large panel of inbred mouse strains to identify a network of genes that are involved in the function of bone-forming osteoblasts, one of the key cell types in determining bone strength.  The authors went on to use the network to elucidate novel genes that are involved in osteoblast-mediated bone formation.  The study revealed novel regulatory mechanisms governing bone formation that may one day be targets of therapies designed to prevent and treat osteoporotic fractures.  Systems Genetic Analysis of Osteoblast-Lineage Cells was published online in PLoS Genetics on December 27, 2012.

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