A research team, led by the Farber lab in the Center for Public Health Genomics and collaborators at UCLA and the University of Namur in Belgium, has used a systems-based approach to identify gene networks that govern the activity of bone cells. The group used genome-wide gene expression data across a large panel of inbred mouse strains to identify a network of genes that are involved in the function of bone-forming osteoblasts, one of the key cell types in determining bone strength. The authors went on to use the network to elucidate novel genes that are involved in osteoblast-mediated bone formation. The study revealed novel regulatory mechanisms governing bone formation that may one day be targets of therapies designed to prevent and treat osteoporotic fractures. Systems Genetic Analysis of Osteoblast-Lineage Cells was published online in PLoS Genetics on December 27, 2012.
The Center for Public Health Genomics was established January, 2007. Our work at the University of Virginia Medical School is focused on translational and personalized medicine — moving gene discovery (and the manner in which genes interact with environment) into the delivery of health care and of disease prevention both in clinical settings as well as in the community.
Center for Public Health Genomics
West Complex
3rd Floor, MSB 3235
1335 Lee Street
Directions
Mail
P.O. Box 800717
Charlottesville, VA 22908
[ 434 ] 982-3228
[ 434 ] 982-1815
Center for Public Health Genomics
West Complex
3rd Floor, MSB 3235
1335 Lee Street
Directions
P.O. Box 800717
Charlottesville, VA 22908
[ 434 ] 982-3228 [ 434 ] 982-1815 
